Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production

Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production

Abstract Background This study evaluated the clinical relevance of a set of five serum-derived circulating microRNAs (miRNAs) in colorectal cancer (CRC). Additionally, we investigated the role of miR-20a-5p released by exosomes derived from cancer-associated fibroblasts (CAFs) in the context of CRC....

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Bibliographic Details
Main Authors: Mahsa Ghofrani-Shahpar, Katayoon Pakravan, Ehsan Razmara, Faezeh Amooie, Mojdeh Mahmoudian, Masoumeh Heshmati, Sadegh Babashah
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Cancer-associated fibroblasts
Exosomes
microRNA
Diagnosis
Online Access:https://doi.org/10.1186/s12885-024-12190-0

Internet

https://doi.org/10.1186/s12885-024-12190-0

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