M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

Abstract Background Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) tetramerization alleviates heart failure, but detailed molecular mechanisms remain unclear. Objective We observed chan...

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Bibliographic Details
Main Authors: Lizhe Guo, Lu Wang, Gang Qin, Junjie Zhang, Jin Peng, Longyan Li, Xiang Chen, Dandan Wang, Jian Qiu, E. Wang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Translational Medicine
Subjects:
Pulmonary arterial hypertension
Right ventricular failure
PKM2 tetramerization
Mitochondrial dynamics
Myocardial apoptosis
Online Access:https://doi.org/10.1186/s12967-023-04780-6

Internet

https://doi.org/10.1186/s12967-023-04780-6

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