M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

Abstract Background Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) tetramerization alleviates heart failure, but detailed molecular mechanisms remain unclear. Objective We observed chan...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Lizhe Guo, Lu Wang, Gang Qin, Junjie Zhang, Jin Peng, Longyan Li, Xiang Chen, Dandan Wang, Jian Qiu, E. Wang
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	BMC 2023-12-01
Σειρά:	Journal of Translational Medicine
Θέματα:	Pulmonary arterial hypertension Right ventricular failure PKM2 tetramerization Mitochondrial dynamics Myocardial apoptosis
Διαθέσιμο Online:	https://doi.org/10.1186/s12967-023-04780-6

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