Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Homozygosity of the p.Arg204Trp variation in the Pleckstrin homology and RhoGEF domain containing G2 (<i>PLEKHG2</i>) gene, which encodes a Rho family-specific guanine nucleotide-exchange factor, is responsible for microcephaly with intellectual disability. However, the role of PLEKHG2 d...

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Bibliografiska uppgifter
Huvudupphovsmän: Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Hiroshi Ueda, Koh-ichi Nagata
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2022-02-01
Serie:Cells
Ämnen:
PLEKHG2
Rho family small GTPases
RhoGEF
brain development
axon guidance
dendrite formation
Länkar:https://www.mdpi.com/2073-4409/11/4/696

Internet

https://www.mdpi.com/2073-4409/11/4/696

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