Early BCR Events and Antigen Capture, Processing and Loading on MHC Class II on B cells

B cells are efficient antigen presenting cells (APCs) by means of antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also ini...

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Bibliographic Details
Main Authors: Ana Maria Avalos, Hidde ePloegh
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00092/full