Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatmen...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Fanxun Zeng, Shiliang Li, Guantian Yang, Yating Luo, Tiantian Qi, Yingfan Liang, Tingyuan Yang, Letian Zhang, Rui Wang, Lili Zhu, Honglin Li, Xiaoyong Xu
التنسيق: مقال
اللغة:English
منشور في: Elsevier 2021-03-01
سلاسل:Acta Pharmaceutica Sinica B
الموضوعات:
DHODH
De novo pyrimidine biosynthesis
DHODH inhibitors
Acrylamide derivatives
Rheumatoid arthritis
الوصول للمادة أونلاين:http://www.sciencedirect.com/science/article/pii/S2211383520307590

الانترنت

http://www.sciencedirect.com/science/article/pii/S2211383520307590

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