Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatmen...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Fanxun Zeng, Shiliang Li, Guantian Yang, Yating Luo, Tiantian Qi, Yingfan Liang, Tingyuan Yang, Letian Zhang, Rui Wang, Lili Zhu, Honglin Li, Xiaoyong Xu
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2021-03-01
Цуврал:Acta Pharmaceutica Sinica B
Нөхцлүүд:
DHODH
De novo pyrimidine biosynthesis
DHODH inhibitors
Acrylamide derivatives
Rheumatoid arthritis
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S2211383520307590

Интернэт

http://www.sciencedirect.com/science/article/pii/S2211383520307590

Ижил төстэй зүйлс