RBD-Based ELISA and Luminex Predict Anti-SARS-CoV-2 Surrogate-Neutralizing Activity in Two Longitudinal Cohorts of German and Spanish Health Care Workers

RBD-Based ELISA and Luminex Predict Anti-SARS-CoV-2 Surrogate-Neutralizing Activity in Two Longitudinal Cohorts of German and Spanish Health Care Workers

ABSTRACT The ability of antibodies to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important correlate of protection. For routine evaluation of protection, however, a simple and cost-efficient anti-SARS-CoV-2 serological assay predictive of serum neutralizing activit...

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Main Authors: Ruth Aguilar, Xue Li, Claudia S. Crowell, Teresa Burrell, Marta Vidal, Rocio Rubio, Alfons Jiménez, Pablo Hernández-Luis, Dieter Hofmann, Hrvoje Mijočević, Samuel Jeske, Catharina Christa, Elvira D'Ippolito, Paul Lingor, Percy A. Knolle, Hedwig Roggendorf, Alina Priller, Sarah Yazici, Carlo Carolis, Alfredo Mayor, Patrik Schreiner, Holger Poppert, Henriette Beyer, Sophia E. Schambeck, Luis Izquierdo, Marta Tortajada, Ana Angulo, Erwin Soutschek, Pablo Engel, Alberto Garcia-Basteiro, Dirk H. Busch, Gemma Moncunill, Ulrike Protzer, Carlota Dobaño, Markus Gerhard
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
neutralization
antibodies
immunoglobulin G
spike protein
receptor binding domain
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03165-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03165-22

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