TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy

TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy

Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for antitumor T cell immunity. However, treatment with anti-CD40 is commonly accompanied by both systemic cytokine release and liver transaminase elevations, which together account for the...

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Bibliographic Details
Main Authors: Meredith L. Stone, Jesse Lee, Veronica M. Herrera, Kathleen Graham, Jae W. Lee, Austin Huffman, Heather Coho, Evan Tooker, Max I. Myers, Michael Giannone, Yan Li, Thomas H. Buckingham, Kristen B. Long, Gregory L. Beatty
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-07-01
Series:JCI Insight
Subjects:
Immunology
Online Access:https://doi.org/10.1172/jci.insight.146314

Internet

https://doi.org/10.1172/jci.insight.146314

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