Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices

Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices

Tight control of beta cell stimulus-secretion coupling is crucial for maintaining homeostasis of energy-rich nutrients. While glucose serves as a primary regulator of this process, incretins augment beta cell function, partly by enhancing cytosolic [Ca2+] dynamics. However, the details of how precis...

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Bibliographic Details
Main Authors: Eva Paradiž Leitgeb, Jasmina Kerčmar, Lidija Križančić Bombek, Vilijem Pohorec, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Gosak, Jurij Dolenšek, Andraž Stožer
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Endocrinology
Subjects:
pancreas
tissue slice
beta cell
calcium imaging
exendin-4
incretin effect
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1315520/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1315520/full

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