Lactobacillus rhamnosus GG and butyrate supplementation in rats with bone cancer reduces mechanical allodynia and increases expression of μ-opioid receptor in the spinal cord

Lactobacillus rhamnosus GG and butyrate supplementation in rats with bone cancer reduces mechanical allodynia and increases expression of μ-opioid receptor in the spinal cord

IntroductionChronic cancer pain is one of the most unbearable symptoms for the patients with advanced cancer. The treatment of cancer pain continues to possess a major challenge. Here, we report that adjusting gut microbiota via probiotics can reduce bone cancer pain (BCP) in rats.MethodsThe model o...

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Bibliographic Details
Main Authors: Wenxi Yuan, Jie Xiao, Huabao Liao, Zhiyuan Xie, Yiran Zhao, Cheng Li, Keying Zhou, Xue-Jun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Lactobacillus rhamnosus GG
cancer pain
mechanical allodynia
μ-opioid receptor
gut microbiota
butyrate
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1207911/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1207911/full

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