2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the benzoxazole moiety, together with the length of th...

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Bibliographic Details
Main Authors: Alma Fuentes-Aguilar, Penélope Merino-Montiel, Sara Montiel-Smith, Socorro Meza-Reyes, José Luis Vega-Báez, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, Andrea Petreni, Alessio Nocentini, Claudiu T. Supuran, Óscar López, José G. Fernández-Bolaños
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
carbonic anhydrases
coumarins
benzoxazoles
antiproliferative agents
docking
Online Access:http://dx.doi.org/10.1080/14756366.2021.1998026

Internet

http://dx.doi.org/10.1080/14756366.2021.1998026

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