Signaling network analysis reveals fostamatinib as a potential drug to control platelet hyperactivation during SARS-CoV-2 infection

Signaling network analysis reveals fostamatinib as a potential drug to control platelet hyperactivation during SARS-CoV-2 infection

IntroductionPro-thrombotic events are one of the prevalent causes of intensive care unit (ICU) admissions among COVID-19 patients, although the signaling events in the stimulated platelets are still unclear.MethodsWe conducted a comparative analysis of platelet transcriptome data from healthy donors...

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Bibliographic Details
Main Authors: Özge Osmanoglu, Shishir K. Gupta, Anna Almasi, Seray Yagci, Mugdha Srivastava, Gabriel H. M. Araujo, Zoltan Nagy, Johannes Balkenhol, Thomas Dandekar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
signaling network
controllability
platelet
SARS-CoV-2
fostamatinib
drug repurposing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1285345/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1285345/full

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