Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma

Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma

IntroductionImmune checkpoint blockade (ICB) is a systemic therapeutic option for advanced hepatocellular carcinoma (HCC). However, low patient response rates necessitate the development of robust predictive biomarkers that identify individuals who will benefit from ICB. A 4-gene inflammatory signat...

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Main Authors: Chun Chau Lawrence Cheung, Yong Hock Justin Seah, Juntao Fang, Nicole Hyacinth Calpatura Orpilla, Mai Chan Lau, Chun Jye Lim, Xinru Lim, Justina Nadia Li Wen Lee, Jeffrey Chun Tatt Lim, Sherlly Lim, Qing Cheng, Han Chong Toh, Su Pin Choo, Suat Ying Lee, Joycelyn Jie Xin Lee, Jin Liu, Tony Kiat Hon Lim, David Tai, Joe Yeong
格式: Article
語言:English
出版: Frontiers Media S.A. 2023-06-01
叢編:Frontiers in Immunology
主題:
LAG-3
CD8
immunotherapy
immune checkpoint blockade
biomarkers
hepatocellular carcinoma
在線閱讀:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150985/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150985/full

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