Enantioselective 5-<i>exo</i>-Fluorocyclization of Ene-Oximes

Enantioselective 5-<i>exo</i>-Fluorocyclization of Ene-Oximes

The enantioselective 5-<i>exo</i>-fluorocyclization of ene-oxime compounds was demonstrated under phase-transfer catalysis. Although deprotonative fluorinations competed, the chemical yields and the ee values of the desired isoxazoline products were generally moderate to good. The absolu...

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Bibliographic Details
Main Authors: Taiki Rouno, Tomoki Niwa, Kousuke Nishibashi, Nobuharu Yamamoto, Hiromichi Egami, Yoshitaka Hamashima
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
fluorine
asymmetric catalysis
phase-transfer catalysis
oxime
Online Access:https://www.mdpi.com/1420-3049/24/19/3464

Internet

https://www.mdpi.com/1420-3049/24/19/3464

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