High population frequencies of MICA copy number variations originate from independent recombination events

High population frequencies of MICA copy number variations originate from independent recombination events

MICA is a stress-induced ligand of the NKG2D receptor that stimulates NK and T cell responses and was identified as a key determinant of anti-tumor immunity. The MICA gene is located inside the MHC complex and is in strong linkage disequilibrium with HLA-B. While an HLA-B*48-linked MICA deletion-hap...

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Bibliographic Details
Main Authors: Anja Klussmeier, Kathrin Putke, Steffen Klasberg, Maja Kohler, Jürgen Sauter, Daniel Schefzyk, Gerhard Schöfl, Carolin Massalski, Gesine Schäfer, Alexander H. Schmidt, Axel Roers, Vinzenz Lange
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
MICA
copy number variation
nonallelic homologous recombination
NAHR
linkage
population frequency
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1297589/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1297589/full

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