PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma

PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma

Summary: Current therapy is ineffective for relapsed and metastatic Ewing sarcoma (EwS) owing to development of drug resistance. Macromolecular prodrugs potentially lead to lower drug exposure in normal tissues and reduced toxicity. We evaluated the efficacy of PEGylated talazoparib (PEG∼TLZ), a PAR...

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Bibliographic Details
Main Authors: Vanessa Del Pozo, Andrew J. Robles, Shaun D. Fontaine, Qianqian Liu, Joel E. Michalek, Peter J. Houghton, Raushan T. Kurmasheva
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:iScience
Subjects:
Oncology
Pharmacology
Molecular medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221016953

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http://www.sciencedirect.com/science/article/pii/S2589004221016953

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