A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium

A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium

In age-related macular degeneration (AMD), both systemic and local zinc levels decline. Elevation of zinc in clinical studies delayed the progression to end-stage AMD. However, the molecular pathways underpinning this beneficial effect are not yet identified. In this study, we used differentiated pr...

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Bibliographic Details
Main Authors: Eszter Emri, Elod Kortvely, Sascha Dammeier, Franziska Klose, David Simpson, EYE-RISK Consortium, Anneke I. den Hollander, Marius Ueffing, Imre Lengyel
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Nutrients
Subjects:
zinc
retinal pigment epithelium
age-related macular degeneration
transcriptome
proteome
secretome
Online Access:https://www.mdpi.com/2072-6643/12/10/3051

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https://www.mdpi.com/2072-6643/12/10/3051

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