Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction

Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction

Summary: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron in AMD, and iron overload triggers RPE cell death in vitro and in vivo....

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Bibliographic Details
Main Authors: Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R.M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007240

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http://www.sciencedirect.com/science/article/pii/S2211124722007240

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