Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction

Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction

Summary: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron in AMD, and iron overload triggers RPE cell death in vitro and in vivo....

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R.M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Elsevier 2022-06-01
Cyfres:Cell Reports
Pynciau:
CP: Immunology
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2211124722007240

Rhyngrwyd

http://www.sciencedirect.com/science/article/pii/S2211124722007240

Eitemau Tebyg