Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease
Summary: Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific immunoglobulin (Ig) A plasma cells are abundant in gut biopsies of patients. Here, we describe the corresponding population of autoreactive B cells in blood. Circulating T...
Main Authors: | Ida Lindeman, Lene S. Høydahl, Asbjørn Christophersen, Louise F. Risnes, Jørgen Jahnsen, Knut E.A. Lundin, Ludvig M. Sollid, Rasmus Iversen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-04-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724003735 |
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