Case Series of 11 <i>CDH1</i> Families (47 Carriers) Including Incidental Findings, Signet Ring Cell Colon Cancer and Review of the Literature

Case Series of 11 <i>CDH1</i> Families (47 Carriers) Including Incidental Findings, Signet Ring Cell Colon Cancer and Review of the Literature

Germline pathogenic variants in E-cadherin (<i>CDH1</i>) confer high risk of developing lobular breast cancer and diffuse gastric cancer (DGC). The cumulative risk of DGC in <i>CDH1</i> carriers has been recently reassessed (from 40–83% by age 80 to 25–42%) and varies accordi...

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Bibliographic Details
Main Authors: Mathis Lepage, Nancy Uhrhammer, Maud Privat, Flora Ponelle-Chachuat, Myriam Kossai, Julien Scanzi, Zangbéwendé Guy Ouedraogo, Mathilde Gay-Bellile, Yannick Bidet, Mathias Cavaillé
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Genes
Subjects:
HDGC
signet ring cell carcinoma
<i>CDH1</i>
E-cadherin
incidental finding
endoscopic finding
Online Access:https://www.mdpi.com/2073-4425/14/9/1677

Internet

https://www.mdpi.com/2073-4425/14/9/1677

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