Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in th...

Full description

Bibliographic Details
Main Authors: Keisuke Takeda, Aoi Uda, Mikihiro Mitsubori, Shun Nagashima, Hiroko Iwasaki, Naoki Ito, Isshin Shiiba, Satoshi Ishido, Masaaki Matsuoka, Ryoko Inatome, Shigeru Yanagi
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01720-2

Internet

https://doi.org/10.1038/s42003-021-01720-2

Similar Items