Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in th...
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Bibliographic Details
| Main Authors: |
Keisuke Takeda,
Aoi Uda,
Mikihiro Mitsubori,
Shun Nagashima,
Hiroko Iwasaki,
Naoki Ito,
Isshin Shiiba,
Satoshi Ishido,
Masaaki Matsuoka,
Ryoko Inatome,
Shigeru Yanagi |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-02-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-021-01720-2
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