Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01720-2 |
| _version_ | 1818432796430958592 |
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| author | Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi |
| author_facet | Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi |
| author_sort | Keisuke Takeda |
| collection | DOAJ |
| description | Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in the transgenic mice model of Alzheimer’s disease. |
| first_indexed | 2024-12-14T16:10:54Z |
| format | Article |
| id | doaj.art-a70a607b38ad4df6980d72a5853d8a14 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T16:10:54Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a70a607b38ad4df6980d72a5853d8a142022-12-21T22:55:00ZengNature PortfolioCommunications Biology2399-36422021-02-014111310.1038/s42003-021-01720-2Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generationKeisuke Takeda0Aoi Uda1Mikihiro Mitsubori2Shun Nagashima3Hiroko Iwasaki4Naoki Ito5Isshin Shiiba6Satoshi Ishido7Masaaki Matsuoka8Ryoko Inatome9Shigeru Yanagi10Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesDepartment of Microbiology, Hyogo College of MedicineDepartment of Pharmacology, Tokyo Medical UniversityLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life SciencesTakeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in the transgenic mice model of Alzheimer’s disease.https://doi.org/10.1038/s42003-021-01720-2 |
| spellingShingle | Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation Communications Biology |
| title | Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation |
| title_full | Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation |
| title_fullStr | Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation |
| title_full_unstemmed | Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation |
| title_short | Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation |
| title_sort | mitochondrial ubiquitin ligase alleviates alzheimer s disease pathology via blocking the toxic amyloid β oligomer generation |
| url | https://doi.org/10.1038/s42003-021-01720-2 |
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