The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD

The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD

The effect of liver steatosis on drug metabolism has been investigated in both preclinical and clinical settings, but the findings of these studies are still controversial. We here evaluated the pharmacokinetic profile of the main sofosbuvir metabolite GS-331007 in healthy animals and rats with non-...

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Bibliographic Details
Main Authors: Daniela Gabbia, Marco Roverso, Samantha Sarcognato, Ilaria Zanotto, Nicola Ferri, Francesco Paolo Russo, Maria Guido, Sara Bogialli, Sara De Martin
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biology
Subjects:
NAFLD
sofosbuvir
HCV
drug metabolism
pharmacokinetics
UMP-CMPK1
Online Access:https://www.mdpi.com/2079-7737/11/5/693

Internet

https://www.mdpi.com/2079-7737/11/5/693

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