Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Abstract A central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Maintenance of the NMJ relies upon neural agrin (n-agrin) which, when released from the nerve ter...

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Bibliographic Details
Main Authors: Qiao Ding, Kaamini Kesavan, Kah Meng Lee, Elyse Wimberger, Thomas Robertson, Melinder Gill, Dominique Power, Jeryn Chang, Atefeh T. Fard, Jessica C. Mar, Robert D. Henderson, Susan Heggie, Pamela A. McCombe, Rosalind L. Jeffree, Michael J. Colditz, Massimo A. Hilliard, Dominic C. H. Ng, Frederik J. Steyn, William D. Phillips, Ernst J. Wolvetang, Shyuan T. Ngo, Peter G. Noakes
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic Lateral Sclerosis
ALS
Neuromuscular junction
MuSK
Agrin
Motor neurons
Online Access:https://doi.org/10.1186/s40478-022-01360-5

Internet

https://doi.org/10.1186/s40478-022-01360-5

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