Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice

Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice

Chronic cerebral hypoperfusion due to carotid artery stenosis is a major cause of vascular cognitive impairment and dementia (VCID). Bilateral carotid artery stenosis (BCAS) in rodents is a well-established model of VCID where most studies have focused on white matter pathology and subsequent cognit...

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Bibliographic Details
Main Authors: Enrique Fraga, Violeta Medina, María Isabel Cuartero, Alicia García-Culebras, Isabel Bravo-Ferrer, Macarena Hernández-Jiménez, Juan Manuel Garcia-Segura, Olivia Hurtado, Jesus Miguel Pradillo, Ignacio Lizasoain, María Ángeles Moro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hypoperfusion
carotid stenosis
neurogenesis
hippocampus
vascular cognitive impairment
dementia
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1219847/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1219847/full

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