Factor VIII antibody immune complexes modulate the humoral response to factor VIII in an epitope-dependent manner

Factor VIII antibody immune complexes modulate the humoral response to factor VIII in an epitope-dependent manner

IntroductionSoluble antigens complexed with immunoglobulin G (IgG) antibodies can induce robust adaptive immune responses in vitro and in animal models of disease. Factor VIII immune complexes (FVIII-ICs) have been detected in individuals with hemophilia A and severe von Willebrand disease following...

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Bibliographic Details
Main Authors: Glaivy Batsuli, Jasmine Ito, Elizabeth S. York, Courtney Cox, Wallace Baldwin, Surinder Gill, Pete Lollar, Shannon L. Meeks
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
B-cell epitope
factor VIII
hemophilia
humoral response
immune complex
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233356/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233356/full

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