Chronic sildenafil citrate use decreases retinal vascular endothelial growth factor expression in diabetic rats: a pilot study

Chronic sildenafil citrate use decreases retinal vascular endothelial growth factor expression in diabetic rats: a pilot study

Abstract Background Sildenafil citrate (SC) attenuates endothelial dysfunction. However, its effects on diabetic retinopathy (DR), which is mainly a microvascular disease, remain unclear. Vascular endothelial growth factor (VEGF) is known to be a critical mediator of DR. Therefore, we investigated t...

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Bibliographic Details
Main Authors: Osama A. Sorour, Elsayed Nassar, Naglaa Sarhan, Noha El-Anwar, Reem A ElKholy, Dina M. Tahoon, Aalaa Sweilam, Dina Tadros
Format: Article
Language:English
Published: BMC 2023-07-01
Series:International Journal of Retina and Vitreous
Subjects:
VEGF
Sildenafil
PDEI-5
Diabetic retinopathy
ELISA
Immunohistochemistry
Online Access:https://doi.org/10.1186/s40942-023-00480-x

Internet

https://doi.org/10.1186/s40942-023-00480-x

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