Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCT

Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCT

Background: Complex trials with innovative designs are becoming increasingly common and offer the potential to improve patient outcomes in a shorter time frame. There is evidence that patients with colorectal cancer fall into different subgroups with varying responsiveness to therapy, and that this...

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Bibliographic Details
Main Authors: Louise C Brown, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Susan D Richman, Philip Quirke, Rachel Butler, Helen Roberts, Janet Graham, Richard H Wilson, Timothy S Maughan
Format: Article
Language:English
Published: NIHR Journals Library 2022-12-01
Series:Efficacy and Mechanism Evaluation
Subjects:
metastatic colorectal cancer
stratified
randomised clinical trial
platform trial
multi-arm
multi-stage
adaptive trial
umbrella trial
biomarker
braf
tp53
ras
pik3ca
wee1
aspirin
adavosertib
her 1,2,3
capecitabine
treatment break
maintenance
chemotherapy
Online Access:https://doi.org/10.3310/HTNB6908

Internet

https://doi.org/10.3310/HTNB6908

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