Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

Mitochondria release many damage-associated molecular patterns (DAMPs) when cells are damaged or stressed, with mitochondrial DNA (mtDNA) being. MtDNA activates innate immune responses and induces inflammation through the TLR-9, NLRP3 inflammasome, and cGAS-STING signaling pathways. Released inflamm...

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Bibliographic Details
Main Authors: Shishi Liao, Jie Luo, Tulanisa Kadier, Ke Ding, Rong Chen, Qingtao Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
mitochondrial DNA1
damage-associated molecular patterns2
inflammation3
ischemia/reperfusion injury4
intestinal barrier function5
systemic inflammatory response syndrome6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.854994/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.854994/full

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