Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Background This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular smooth muscle cells (VSMCs) and atherosclerosis i...

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Bibliographic Details
Main Authors: Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Shenming Wang
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
ATP‐binding cassette transporter
foam cells
Lipid metabolites
Nod like receptor family, pyrin domain‐containing 3 protein
receptor for advanced glycation end product
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.008596

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.008596

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