Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [<sup>99m</sup>Tc]mebrofenin Imaging in Rats
The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of drugs and metabolites. [<sup>99m</sup>Tc]mebrofenin may be employed as a probe for hepatic MRP2 activity because its biliary excretion is predominantly mediated by this transporter. As the liver uptake...
| Príomhchruthaitheoirí: | , , , , , , , , |
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| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
MDPI AG
2020-05-01
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| Sraith: | Pharmaceutics |
| Ábhair: | |
| Rochtain ar líne: | https://www.mdpi.com/1999-4923/12/6/486 |