Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [<sup>99m</sup>Tc]mebrofenin Imaging in Rats

Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [<sup>99m</sup>Tc]mebrofenin Imaging in Rats

The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of drugs and metabolites. [<sup>99m</sup>Tc]mebrofenin may be employed as a probe for hepatic MRP2 activity because its biliary excretion is predominantly mediated by this transporter. As the liver uptake...

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Bibliographic Details
Main Authors: Solène Marie, Irene Hernández-Lozano, Louise Breuil, Wadad Saba, Anthony Novell, Jean-Luc Gennisson, Oliver Langer, Charles Truillet, Nicolas Tournier
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
drug-induced liver injury
drug metabolism
imaging
liver
membrane transporter
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/12/6/486

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