Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

Microtubule (MT) associated protein tau is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs), which manifest as neurofibrillary tangles (NFTs) in the brains of individuals with Alzheimer’s disease (AD) and related tauopathies. Hyperphosphorylation and truncation of t...

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Bibliographic Details
Main Authors: Yan Zhou, Jianhua Shi, Dandan Chu, Wen Hu, Zongyu Guan, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
tau
hyperphosphorylation
truncation
tau pathogenesis
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00027/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2018.00027/full

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