Promoter conservation in HDACs points to functional implications

Abstract Background Histone deacetylases (HDACs) are the proteins responsible for removing the acetyl group from lysine residues of core histones in chromosomes, a crucial component of gene regulation. Eleven known HDACs exist in humans and most other vertebrates. While the basic function of HDACs h...

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Bibliographic Details
Main Authors: Toni A. Boltz, Sawsan Khuri, Stefan Wuchty
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12864-019-5973-x