The capacity of red blood cells to reduce nitrite determines nitric oxide generation under hypoxic conditions.

The capacity of red blood cells to reduce nitrite determines nitric oxide generation under hypoxic conditions.

Nitric oxide (NO) is a key regulator of vascular tone. Endothelial nitric oxide synthase (eNOS) is responsible for NO generation under normoxic conditions. Under hypoxia however, eNOS is inactive and red blood cells (RBC) provide an alternative NO generation pathway from nitrite to regulate hypoxic...

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Bibliographic Details
Main Authors: Marcel H Fens, Sandra K Larkin, Bryan Oronsky, Jan Scicinski, Claudia R Morris, Frans A Kuypers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4090171?pdf=render

Internet

http://europepmc.org/articles/PMC4090171?pdf=render

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