Multivariate modular metabolic engineering and medium optimization for vitamin B12 production by Escherichia coli

Multivariate modular metabolic engineering and medium optimization for vitamin B12 production by Escherichia coli

Vitamin B12 is a complex compound synthesized by microorganisms. The industrial production of vitamin B12 relies on specific microbial fermentation processes. E. coli has been utilized as a host for the de novo biosynthesis of vitamin B12, incorporating approximately 30 heterologous genes. However,...

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Bibliographic Details
Main Authors: Feitao Chen, Huan Fang, Jianghua Zhao, Pingtao Jiang, Huina Dong, Ying Zhao, Huiying Wang, Tongcun Zhang, Dawei Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-09-01
Series:Synthetic and Systems Biotechnology
Subjects:
Vitamin B12
Multivariate modular metabolic engineering
E. coli
Organic nitrogen sources
Fed-batch fermentation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000516

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http://www.sciencedirect.com/science/article/pii/S2405805X24000516

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