Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver.

Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver.

Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver of Irs-2 deficient mice and Irs2(-/-) mice whe...

Full description

Bibliographic Details
Main Authors: Isabel Roncero, Elvira Alvarez, Carlos Acosta, Carmen Sanz, Pedro Barrio, Veronica Hurtado-Carneiro, Deborah Burks, Enrique Blázquez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3613347?pdf=render

Internet

http://europepmc.org/articles/PMC3613347?pdf=render

Similar Items