“Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”

“Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”

Abstract Background Patient-derived organoids (PDOs) from advanced colorectal cancer (CRC) patients could be a key platform to predict drug response and discover new biomarkers. We aimed to integrate PDO drug response with multi-omics characterization beyond genomics. Methods We generated 29 PDO lin...

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Bibliographic Details
Main Authors: Federica Papaccio, Blanca García-Mico, Francisco Gimeno-Valiente, Manuel Cabeza-Segura, Valentina Gambardella, María Fernanda Gutiérrez-Bravo, Clara Alfaro-Cervelló, Carolina Martinez-Ciarpaglini, Pilar Rentero-Garrido, Sheila Zúñiga-Trejos, Juan Antonio Carbonell-Asins, Tania Fleitas, Susana Roselló, Marisol Huerta, Manuel M. Sánchez del Pino, Luís Sabater, Desamparados Roda, Noelia Tarazona, Andrés Cervantes, Josefa Castillo
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Organoids
Quantitative proteomics
Precision medicine
Drug resistance
Transcriptomics
Online Access:https://doi.org/10.1186/s13046-022-02591-z

Internet

https://doi.org/10.1186/s13046-022-02591-z

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