Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth

Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth

Abstract Background Although molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully applied for clinical treatment. Therefore, it is urgent to discover novel actionable targets and inhibitors. Eukaryotic translational elongation f...

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Bibliographic Details
Main Authors: Xuechao Jia, Penglei Wang, Chuntian Huang, Dengyun Zhao, Qiong wu, Bingbing Lu, Wenna Nie, Limeng Huang, Xueli Tian, Pan li, Kyle Vaughn Laster, Yanan Jiang, Xiang Li, Honglin Li, Zigang Dong, Kangdong Liu
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ESCC
eEF2
RIP-Sequence
ITC
Toosendanin
Online Access:https://doi.org/10.1186/s13046-023-02666-5

Internet

https://doi.org/10.1186/s13046-023-02666-5

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