SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential

SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential

Summary: Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance. To date, the phenotypes of SARS-CoV-2-specific T cells remain poorly defined. Using 38-parameter CyTOF, we phenotyped longi...

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Bibliographic Details
Main Authors: Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Gurjot Gill, Ellen S. Stein, Matthew McGregor, Tongcui Ma, Ashley F. George, Astrid Kosters, Warner C. Greene, Joshua Vasquez, Eliver Ghosn, Sulggi Lee, Nadia R. Roan
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports Medicine
Subjects:
SARS-CoV-2
COVID-19
T cells
CD127
IL7
homeostatic proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120301026

Internet

http://www.sciencedirect.com/science/article/pii/S2666379120301026

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