Genetic polymorphisms in tumour necrosis factor receptors (TNFRSF1A/1B) illustrate differential treatment response to TNFα inhibitors in patients with Crohn’s disease

BackgroundMonoclonal antibodies inhibiting tumour necrosis factor-α (TNFα) signalling pathway (anti-TNFα) have been widely used in Crohn’s disease (CD). However, treatment response varies among patients with CD and the clinical outcome is dependent on single nucleotide polymorphisms (SNP) in TNFα r...

Полное описание

Библиографические подробности
Главные авторы: Ahmad Qasem, Saleh A Naser, Seela Ramesh
Формат: Статья
Язык:English
Опубликовано: BMJ Publishing Group 2019-06-01
Серии:BMJ Open Gastroenterology