Case Report: Simultaneous Hyperprogression and Fulminant Myocarditis in a Patient With Advanced Melanoma Following Treatment With Immune Checkpoint Inhibitor Therapy

Case Report: Simultaneous Hyperprogression and Fulminant Myocarditis in a Patient With Advanced Melanoma Following Treatment With Immune Checkpoint Inhibitor Therapy

We report here a patient with stage IV mucosal melanoma treated with dual immune checkpoint inhibitor (ICI) therapy (Nivolumab/Ipilimumab) who experienced rapid disease progression and metastatic spread within three weeks of first infusion. Surprisingly, this patient also developed fulminant myocard...

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Bibliographic Details
Main Authors: Whitney Barham, Ruifeng Guo, Sean S. Park, Joerg Herrmann, Haidong Dong, Yiyi Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
melanoma
immune checkpoint inhibitors
hyperprogression
myocarditis
cytolytic T lymphocytes
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.561083/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.561083/full

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