SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

The pathogenesis of COVID-19 is associated with a hyperinflammatory response; however, the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. Here, we investigated direct inflammatory functions of major structural proteins of SARS-CoV-2. We observed that spike (S) protein pot...

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Bibliographic Details
Main Authors: Shahanshah Khan, Mahnoush S Shafiei, Christopher Longoria, John W Schoggins, Rashmin C Savani, Hasan Zaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
SARS-CoV-2
COVID-19
spike protein
cytokine storm
TLR2
inflammation
Online Access:https://elifesciences.org/articles/68563

Internet

https://elifesciences.org/articles/68563

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