FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification (TRAP) in conditionally tagged mice to precis...

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Bibliographic Details
Main Authors: Caryn R Hale, Kirsty Sawicka, Kevin Mora, John J Fak, Jin Joo Kang, Paula Cutrim, Katarzyna Cialowicz, Thomas S Carroll, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
local translation
FMRP
RNA-binding proteins
synaptic plasticity
mRNA localization
Online Access:https://elifesciences.org/articles/71892

Internet

https://elifesciences.org/articles/71892

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