Optimal marker gene selection for cell type discrimination in single cell analyses

The selection of a small set of cellular labels to distinguish a subpopulation of cells from a complex mixture is an important task in cell biology. Here the authors propose a method for supervised genetic marker selection using linear programming and provides a Python package scGeneFit that impleme...

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Bibliographic Details
Main Authors: Bianca Dumitrascu, Soledad Villar, Dustin G. Mixon, Barbara E. Engelhardt
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21453-4