Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs

Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs

Abstract Background Melanoma is the most serious type of skin cancer, and surgery is an effective method to treat melanoma. Unfortunately, local residual micro-infiltrated tumour cells and systemic circulating tumour cells (CTCs) are significant causes of treatment failure, leading to tumour recurre...

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Bibliographic Details
Main Authors: Jian Zhao, Hao Ye, Qi Lu, Kaiyuan Wang, Xiaofeng Chen, Jiaxuan Song, Helin Wang, Yutong Lu, Maosheng Cheng, Zhonggui He, Yinglei Zhai, Haotian Zhang, Jin Sun
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Nanobiotechnology
Subjects:
Recurrence
Metastasis
Drug reservoir
Platelet-derived small EVs
PD-L1
Online Access:https://doi.org/10.1186/s12951-022-01270-7

Internet

https://doi.org/10.1186/s12951-022-01270-7

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