Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1β in hepatocytes

Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1β in hepatocytes

Interleukin-1β (IL-1β) is a major inducer of liver acute-phase protein expression in response to infection. Several transcription factors, including CCAAT/enhancer binding protein (C/EBP), are known mediators in this process, although the mechanisms by which they modulate IL-1β's action are not...

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Bibliographic Details
Main Authors: Natalia V. Giltiay, Alexander A. Karakashian, Alexander P. Alimov, Sandy Ligthle, Mariana N. Nikolova-Karakashian
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Journal of Lipid Research
Subjects:
inflammation
sphingomyelinase
liver
acute-phase protein
extracellular signal-regulated kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328881

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http://www.sciencedirect.com/science/article/pii/S0022227520328881

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